Directory

2016

2015

2014

2013

2011-2012

2010

2009

2005-2008

Before 2005

Education Publications

 

 

 

 

• 2016

Reduced haemodynamic coupling and exercise are associated with vascular stiffening in pulmonary arterial hypertension.
Bellofiore A, Dinges E, Naeije R, Mkrdichian H, Beussink-Nelson L, Bailey M, Cuttica MJ, Sweis R, Runo JR, Keevil JG, Francois CJ, Shah SJ, Chesler NC.
Heart, 2016.

Estrogen preserves pulsatile pulmonary arterial hemodynamics in pulmonary arterial hypertension.
Liu A, Hacker T, Eickhoff JC, Chesler NC.
Ann Biomed Eng, 2016.

17β-estradiol mediates superior adaptation of right ventricular function to acute strenuous exercise in female rats with severe pulmonary hypertension.
Lahm T, Frump AL, Albrecht AL, Fisher AJ, Cook TG, Jones TJ, Yakubov B, Whitson J, Fuchs RK, Liu A, Chesler NC, Brown MB.
Amer J Physiol Lung Cell Mol Physiol, 2016.

Heterogeneous mechanics of the mouse pulmonary arterial network.
Lee P, Carlson BE, Chesler NC, Olufsen MS, Qureshi UM, Smith NP, Sochi T, Beard DA.
Biomech Model Mechanobiol, 2016.

Imaging right ventricular function to predict outcome in pulmonary arterial hypertension.
Brewis MJ, Bellofiore A, Vanderpool RR, Chesler NC, Johnson MK, Naeije R, Peacock AJ.
International J of Cardiology, 218: 206-211. 2016.

Limiting collagen turnover via collagenase-resistance attenuates right ventricular dysfunction and fibrosis in pulmonary arterial hypertension.
Golob MJ, Wang W, Prostrollo AJ, Hacker TA, Chesler NC.
Physiological Reports, 4(11): e12815. 2016.

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• 2015

Magnetic resonance and computed tomography imaging for the evaluation of pulmonary hypertension.
Freed B, Collins J, Francois C, Barker A, Cuttica M, Chesler NC, Markl M, Shah S.
JACC Cardiovascular Imaging, 2015.

Increased red blood cell stiffness increases pulmonary vascular resistance and pulmonary arterial pressure.
Schreier, D. A., Forouzan, O., Hacker, T. A., Sheehan, J., & Chesler, N. Journal of Biomechanical Engineering J Biomech Eng, 138(2), 021012. doi:10.1115/1.4032187, 2015.

Non-invasive measurement using cardiovascular magnetic resonance of changes in pulmonary artery stiffness with exercise.
Forouzan, O., Warczytowa, J., Wieben, O., François, C. J., & Chesler, N. C. Journal of Cardiovascular Magnetic Resonance J Cardiovasc Magn Reson, 17(1). doi:10.1186/s12968-015-0213-2, 2015.

Validation of an arterial constitutive model accounting for collagen content and crosslinking.
Tian, L., Wang, Z., Liu, Y., Eickhoff, J. C., Eliceiri, K. W., & Chesler, N. C. Acta Biomaterialia, 31, 276-287. doi:10.1016/j.actbio.2015.11.058, 2015.

17β-estradiol attenuates conduit pulmonary artery mechanical property changes with pulmonary arterial hypertension.
Liu, A., Tian, L., Golob, M., Eickhoff, J. C., Boston, M., & Chesler, N. C. Hypertension, 66(5), 1082-1088. doi:10.1161/hypertensionaha.115.05843, 2015.

What does the time constant of the pulmonary circulation tell us about the progression of right ventricular dysfunction in pulmonary arterial hypertension?
Bellofiore, A., Wang, Z., & Chesler, N. C. Pulmonary Circulation, 5(2), 291-295. doi:10.1086/680358, 2015.

Stretch calculated from grip distance accurately approximates mid-specimen stretch in large elastic arteries in uniaxial tensile tests.
Tian, L., Henningsen, J., Salick, M. R., Crone, W. C., Gunderson, M., Dailey, S. H., & Chesler, N. C. Journal of the Mechanical Behavior of Biomedical Materials, 47, 107-113. doi:10.1016/j.jmbbm.2015.03.016, 2015.

Accuracy of doppler echocardiographic estimates of pulmonary artery pressures in a canine model of pulmonary hypertension.
Soydan LC, Kellihan HB, Bates ML, Stepien RL, Consigny DW, Bellofiore A, Francois CJ, Chesler NC. J Vet Cardiol, DOI: 10.1016/j.jvc.2014. 2015.

A novel in vivo approach to assess radial and axial distensibility of large and intermediate pulmonary artery branches.
Bellofiore A, Henningsen J, Lepak CG, Tian L, Roldan-Alzate A, Kellihan HB, Consigny DW, Francois CJ, Chesler NC. J Biomech Eng, DOI: 10.1115/1.4029578. 2015.

Mitochondria DNA mutations cause sex-dependent development of hypertension and alterations in cardiovascular function.
Golob MJ, Tian L, Wang Z, Zimmerman TA, Caneba CA, Hacker TA, Song G, Chesler NC. J Biomech, 48(3): 405-412. 2015.

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• 2014

Impact of hematocrit on right ventricular afterload during the progression of hypoxic pulmonary hypertension.
Schreier DA, Hacker T, Hunder KS, Eickoff J, Liu A, Song G, Chesler NC. J Appl Physiol, 117(8): 833-839. 2014.

Pulmonary artery relative area change is inversely related to ex vivo measured arterial elastic modulus in the canine model of acute pulmonary embolization.
Tian L, Kellihan HB, Henningsen J, Bellfiore A, Forouzan O, Roldan-Alzate A, Consigny DW, Gunderson M, Dailey SH, Francois CJ, Chesler NC. J biomech, DOI: 10.1016/j.jbiomech.2014.07.013. 2014.

Cardiac tissue structure, properties, and performance: A materials science perspective.
Golob M, Moss RL, Chesler NC. Ann Biomed Engr, DOI: 10.1007/s10439-014-1071-z. 2014.

4D flow assessment of pulmonary artery flow and wall shear stress in adult pulmonary arterial hypertension: Results from two institutions.
Barker AJ, Roldan-Alzate A, Entezari P, Shah SJ, Chesler NC, Wieben O, Markl M, Francois CJ. Magnetic Resonance in Medicine, DOI: 10.1002/mrm.25326. 2014

Direct and Indirect protection of right ventricular function by estrogen in an experimental model of pulmonary arterial hypertension.
Liu A, Schreier D, Lian T, Eickhoff JC, Wang Z, Hacker T, Chesler NC. Am J Physiol Heart Circ Physiol, DOI: 10.1152/ajpheart.00758.2013. 2014

Low cost MRI-compatible stepper exercise device for use cardiac stress tests.
Forouzan O, Flink E, Warczytowa J, Thate N, Hanske A, Lee T, Roldan-Alzate A, Francois C, Wieben O, Chesler NC. J Med Devices, DOI: 10.1115/1.4027343. 2014

Non-invasive assessment of cardiac function and pulmonary vascular resistance in an canine model of acute thromboembolic pulmonary hypertension using 4D flow cardiovascular magnetic resonance.
Roldan-Alzate A, Frydrychowicz A, Johnson KM, Kellihan H, Chesler NC, Wieben O, Francois CJ. J Cardiovasc Magn Reson, DOI: 10.1186/1532-429X-16-23. 2014

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• 2013

Progressive right ventricular function and structural changes in a mouse model of pulmonary arterial hypertension.
Wang Z, Schreier DA, Hacker T, Chesler NC. Physiol Reports, DOI: 10.1002/phy2.184. 2013

Analysis of cardiovascular dynamics in pulmonary hypertensive C57BL6/J mice.
Tewari SG, Bugenhagen SM, Wang Z, Schreier DA, Carlson BE, Chesler NC, Beard DA. Front Physiol, 4(355), 2013.

Changes in large pulmonary arterial viscoelasticity in chronic pulmonary hypertension.
Wang Z, Lakes RS, Golob M, Eickhoff JC, Chesler NC. PLoS One, 8(11): e78569. 2013.

4D flow-sensitive MR estimation of pulmonary vascular resistance.
Roldan-Alzate A, Francois C, Wieben O, Chesler NC, Frydrychowicz A. J Cardiovasc Magn Reson, 15(1): 128. 2013.

Pulmonary vascular mechanics: important contributors to the increased right ventricular afterload of pulmonary hypertension.
Wang Z, Chesler NC. Exp Physiol, 98(8): 1267-1273. 2013.

Comparison of approaches to quantify arterial damping capacity from pressurization tests on mouse conduit arteries.
Tian L, Wang Z, Lakes RS, Chesler NC. J Biomech Eng, 135(5), 2013.

Magnetic resonance and computed tomography imaging of the structural and functional changes of pulmonary arterial hypertension.
Shiebler ML, Bhalla S, Runo J, Jarjour N, Roldan A, Chesler NC, Francois CJ. Journal of Thoracic Imaging, 28(3): 178-195. 2013.

The role of collagen synthesis in ventricular and vascular adaptation to hypoxic pulmonary hypertension.
Schreier DA, Hacker T, Song G, Chesler NC. J Biomech Eng. 135(2): 021008, 2013.

Methods for measuring right ventricular function and hemodynamic coupling with the pulmonary vasculature.
Bellofiore A, Chesler NC. Ann Biomed Eng, 41(7): 1384-1398, 2013.

Blood pressure, artery size, and artery compliance parallel bone size and strength in mice with differing ece1 expression.
Wang Z, Kristianto J, Ooi CY, Johnson MG, Litscher SJ, Pugh T, Sandhu G, Chesler NC, Blank RD. J Biomech Eng. 135(6) 61003-61009, 2013.

Effects of collagen deposition on passive and active mechanical properties of large pulmonary arteries in hypoxic pulmonary hypertension.
Wang Z, Lakes RS, Eickhoff JC, Chesler NC. Biomech Model Mechanobiol. 12(6): 1115-1125, 2013.

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• 2011 to 2012

Exercise stress echocardiography of the pulmonary circulation: limits of normal and sex differences.
Argiento P, Vanderpool RR, Mule M, Russo MG, D'Alto M, Bossone E, Chesler NC, Naeije R. Chest, 142(5): 1158–1165. 2012.

Impact of acute pulmonary embolization on arterial stiffening and right ventricular function in dogs.
Bellofiore A, Roldán-Alzate A, Besse M, Kellihan HB, Consigny DW, Francois CJ, Chesler NC. Ann Biomed Eng, 41(1): 195–204. 2012.

In vivo and in vitro measurements of pulmonary arterial stiffness: A brief review.
Tian L, Chesler NC. Pulmonary Circulation,  2(4): 505–517. 2012.

Role of collagen content and cross-linking in large pulmonary arterial stiffening after chronic hypoxia.
Wang Z, Chesler NC. Biomech Model Mechanobiol, 11(1-2): 279–289. 2012.

Patchy deletion of Bmpr1a potentiates proximal pulmonary artery remodeling in mice exposed to chronic hypoxia.
Vanderpool RR, El-Bizri N, Rabinovitch M, Chesler NC. Biomechanics and Modeling in Mechanobiology. 12(1): 33-42 2012.

Persistent vascular collagen accumulation alters hemodynamic recovery from chronic hypoxia.
Tabima D, Roldan-Alzate A, Wang Z, Hacker T, Molthen R, Chesler NC. Journal of Biomechanics. 45: 799–804. 2012.

Pulmonary circulation at exercise.
Naeije R, Chesler NC. Comprehensive Physiology. John Wiley & Sons, Inc. 2: 711-741. 2012.

Pulmonary vascular wall stiffness: An important contributor to increased right ventricular afterload in pulmonary hypertension.
Wang Z, Chesler NC. Pulmonary Circulation. 1(2): 212-23. 2011.

Characterization of the isolated, ventilated and instrumented mouse lung perfused with pulsatile flow.
Vanderpool RR, Chesler NC. Journal of Visualized Experiments. 50: e2690. 2011.

Effects of acute rho kinase inhibition on chronic hypoxia-induced changes in proximal and distal pulmonary arterial structure and function.
Vanderpool RR, Kim AR, Molthen R, Chesler NC. Journal of Applied Physiology, 110(1):188-98. 2011.

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• 2010

Measuring right ventricular function in the normal and hypertensive mouse hearts using admittance-derived pressure-volume loops.
Tabima DM, Hacker TA, Chesler NC. American Journal of Physiology – Heart and Circulatory Physiology, 299(6):H2069-75. 2010.

The role of collagen in extralobar pulmonary artery stiffening in response to hypoxia-induced pulmonary hypertension.
Ooi CY, Wang Z, Tabima DM, Eickhoff JC, Chesler NC. Am J Physiol Heart Circ Physiol 299:H1823-H1831, doi:10.1152/ajpheart.00493.2009. First published 17 September 2010;

The effects of vaso activity and hypoxic pulmonary hypertensionon extralobar pulmonary artery biomechanics.
Tabima DM, Chesler NC. Journal of Biomechanics, 43(10):1864-9. 2010.

Time course of intermittent hypoxia-induced impairments in resistance artery structure and function.
Philippi N, Bird C, Marcus N, Olson E, Chesler NC, Morgan B. Respiratory Physiology & Neurobiology 170, 157–163. 2010.

Impedance in isolated mouse lungs for the determination of site of action of vasoactive agents and disease.
Vanderpool RR, Naeije R, Chesler NC. Annals of Biomedical Engineering. Feb 2010

Shear stress regulation of nitric oxide production in uterine and placental artery endothelial cells: experimental studies and hemodynamic models of shear stress forces on endothelial cells.
Sprague BJ, Chesler NC, Magness RR. International Journal of Developmental Biology. 54(2-3):331-9. 2010.

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• 2009

Exercise stress echocardiography for the study of the pulmonary circulation.
Argiento P, Chesler NC, Mulè M, D'Alto M, Bossone E, Unger P, Naeije R. Eur Respir J. 2009.

Characterization of CSF hydrodynamics in the presence and absence of tonsilar ectopia by means of computational flow analysis.

Roldan A, Haughton VM, Wieben O, Osswald T, Chesler NC. American Journal of Neuroradiology. 30:941-946. 2009.

Collagen-related gene and protein expression changes in the lung in response to chronic hypoxia.
Estrada KD, Chesler NC. Biomechanics and Modeling in Mechanobiology. 8(4): 263–272. 2009.

The effects of the ovarian cycle and pregnancy on uterinevascular impedance and uterine artery mechanics.
Sprague BJ, Phernetton TM, Magness RR, Chesler NC. European Journal of Obstetrics and Gynecology and Reproductive Biology. 2009.

Transmission line models to simulate the impedance of the uterine vasculature during the ovarian cycle and pregnancy.
Zhu Y, Sprague BJ, Phernetton TM, Magness RR, Chesler NC. European Journal of Obstetrics and Gynecology and Reproductive Biology. 2009.

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• 2005-2008

Chronic hypoxia-induced pulmonary hypertension does lead to loss of pulmonary vasculature. Rabinovitch M, Chesler NC, Molthen RC. Journal of Applied Physiology 103: 1449-1451. 2007.

The mechanobiology of pulmonary vascular remodeling in the congenital absence of eNOS. Kobs RW, Chesler NC. Biomechanics and Modeling in Mechanobiology 5(4):217-225. 2006.

Pulmonary vascular remodeling in isolated mouse lungs: Effects on pulsatile pressure–flow relationships.
Tuchscherer HA, Vanderpool RR, Chesler NC. Journal of Biomechanics. 40: 993-1001. 2007

Pulmonary vascular resistance and impedance in isolated mouse lungs: Effects of pulmonary emboli.
Tuchscherer HA, Webster E and Chesler NC. Annals of Biomedical Engineering. 34(4):660-668. 2006.

Pressure-induced vector transport in human saphenous vein.
*Ander S, *MacLennan M, Bentil S, Leavitt B, Chesler NC. Annals of Biomedical Engineering. 33: 202-208. 2005. (*These authors contributed equally).

A method for dynamic system characterization using hydraulic series resistance.
Kim D, Chesler NC, Beebe DJ. Lab on a Chip. 6: 639-664. 2006.

Linked Mechanical and biological aspects of pulmonary vascular remodeling with hypoxia-induced hypertension in mice.
Kobs RW, Eickhoff JE, Muvarak NE, Chesler, NC. American Journal of Physiology: Heart & Circulatory Physiology. 288: H1209-17, 1209-1217. 2005.

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• Before 2005

Measurements of mouse pulmonary artery biomechanics.
Chesler NC, Thompson-Figueroa J, Millburne K. Journal of Biomechanical Engineering. 126: 309-313. April 2004.

Mechanical properties of rat middle cerebral arteries with and without myogenic tone.
Coulson R, Cipolla MJ, Vitullo L and Chesler NC. Journal of Biomechanical Engineering. 126: 76-81. February 2004.

Hypoxia-induced changes in the mechanical properties of the mouse pulmonary artery.
Kobs RW, Muvarak NE, Chesler NC. 2003 ASME M.S. Paper Competition.

Particle deposition in arteries ex vivo: Effects of pressure, flow and waveform.
Chesler NC, Enyinna OC. Journal of Biomechanical Engineering. 125: 389-394. June 2003.

Effects of ischemia and myogenic reactivity on the active and passive mechanical properties of rat cerebral arteries.
Coulson R, Chesler NC, Vitullo L, Cipolla MJ. American Journal of Physiology: Heart & Circulatory Physiology. 283(6):H2268-75. 2002.

Early effects of arterial hemodynamic conditions on human saphenous vein perfused ex vivo.
Mavromatis K, Fukai T, Tate M, Chesler NC, Ku D, Galis ZS. Arteriosclerosis, Thrombosis and Vascular Biology, 20(8): 1889-95. Aug 2000.

Transmural pressure induces matrix-degrading activity in porcine arteries ex vivo.
Chesler NC, Ku DN, Galis ZS. American Journal of Physiology 277 (Heart Circ. Physiol. 46): H2002-H2009. 1999.

Simplified ex vivo culture techniques for porcine arteries.
Chesler NC, Conklin BS, Han HC, Ku DN. Journal of Vascular Investigation, 4: 123-127. 1998.

Performance analysis of a cardiac assist device in counterpulsation.
Chesler NC, Kamm RD. Journal of Biomechanical Engineering, 120: 437-445. 1998.

Surface EMG as a fatigue indicator during FES-aided standing.
Chesler NC, Durfee W. Journal of Electrophysiology and Kinesiology, 7 (1): 27-37. 1997.

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• Education Publications

Teaching and Assessing Engineering Design Thinking with Virtual Internships and Epistemic Network Analysis.
Arastoopour G, Shaffer DW, Swiecki Z, Ruis JR, Chesler NC. International Journal of Engineering Education, 2015.

A novel paradigm for engineering education: virtual internships with individualized mentoring and assessment of engineering thinking.
Chesler NC, Ruis AR, Collier W, Swiecki Z, Arastoopour G, Shaffer DW. J Biomech Eng, 137(2) DOI:10.1115/1.1029235. 2014.

Epistemic persistence: A simulation-based approach to increasing participation of women in engineering.
Arastoopour G, Chesler NC, Shaffer DW. Journal of Women and Minorities in Science and Engineering, DOI: 10.1615/JWomenMinorScienEng.2014 007317. 2014.

Development of concept-based physiology lessons for biomedical engineering undergraduate students.
Nelson RK, Chesler NC, Strang KT. Adv Physiol Educ, 37(2): 176-183 2013.

Design of a Professional Practice Simulator for Educating and Motivating First-Year Engineering Students.
Chesler NC, Arastoopour G, D’Angelo CM, Bagley EA, Shaffer DW. Advances in Engineering Education, 3(3): 1-29 2012.

The Pipeline still leaks and more than you think: A Status report on gender diversity in biomedical engineering.
Chesler NC, Barabino G, Bhatia SN, Richards-Kortum R. Annals of Biomedical Engineering, 38(5): 1928-35. Epub. Feb 17 2010.

Human respiratory mechanics demonstration model.
Anderson J, Goplen C, Murray L, Seashore K, Soundarrajan M, Lokuta A, Strang K, Chesler NC. Advances in Physiology Education, 33(1): 53-59. 2009.

Theater as a community-building strategy for women in engineering: theory and practice.
Chesler NC, Chesler MA. Journal of Women and Minorities in Science and Engineering, 11: 83-95. 2005.

On belay: Peer-mentoring and adventure education for women faculty in engineering.
Chesler NC, Single PB, Mikic B. Journal of Engineering Education, 257-262. July 2003.

Gender-informed mentoring strategies for women in engineering: On establishing a caring community.
Chesler NC, Chesler MA. Journal of Engineering Education, 91(1): 49-56. Jan 2002.

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